Ontology highlight
ABSTRACT:
SUBMITTER: Martin S
PROVIDER: S-EPMC2941718 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Pigment cell & melanoma research 20100712 5
Targeting endoplasmic reticulum stress-induced apoptosis may offer an alternative therapeutic strategy for metastatic melanoma. Fenretinide and bortezomib induce apoptosis of melanoma cells but their efficacy may be hindered by the unfolded protein response, which promotes survival by ameliorating endoplasmic reticulum stress. The aim of this study was to test the hypothesis that inhibition of GRP78, a vital unfolded protein response mediator, increases cell death in combination with endoplasmic ...[more]