Ontology highlight
ABSTRACT:
SUBMITTER: Heitor da Silva Maues J
PROVIDER: S-EPMC7803532 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Heitor da Silva Maués Jersey J Ferreira Ribeiro Helem H de Maria Maués Sacramento Raquel R Maia de Sousa Rafael R Pereira de Tommaso Raíssa R Dourado Kovacs Machado Costa Bruno B Cardoso Soares Paulo P Pimentel Assumpção Paulo P de Fátima Aquino Moreira-Nunes Caroline C Mário Rodriguez Burbano Rommel R
Aging 20201222 24
<i>MYC</i> overexpression is a common phenomenon in gastric carcinogenesis. In this study, we identified genes differentially expressed with a downregulated profile in gastric cancer (GC) cell lines with silenced MYC. The <i>TTLL12</i>, <i>CDKN3</i>, <i>CDC16</i>, <i>PTPRA</i>, <i>MZT2B</i>, <i>UBE2T</i> genes were validated using qRT-PCR, western blot and immunohistochemistry in tissues of 213 patients with diffuse and intestinal GC. We identified high levels of <i>TTLL12</i>, <i>MZT2B</i>, <i> ...[more]