Dataset Information

Effects of age-related breathing characteristics on the performance of four-dimensional magnetic resonance imaging reconstructed by prospective gating for radiation therapy planning.

ABSTRACT:

Background and purpose

Four-dimensional magnetic resonance imaging (4D MRI) has advanced recently by incorporating prospective gating, but its performance on pediatric populations has not been investigated. This study aimed to determine the age-related performance of prospective gating, as compared with retrospective sorting.

Materials and methods

Prospectively gated 4D MRI scans were acquired on a motion phantom driven by real respiratory waveforms obtained from 23 pediatric and young adult patients (aged 5-24?years). The correlations between patient-specific breathing characteristics and the performance of 4D MRI were comparatively evaluated against retrospective sorting for the same scan time. For six patients who underwent both 4D MRI and 4D CT, the internal target volumes (ITVs) determined by the two modalities were compared.

Results

Longer scan time and greater sorting error were most highly correlated (P?30%). The ITVs of 4D MRI and 4D CT were comparable (Dice similarity: >90%) unless the breathing characteristics changed between the two imaging sessions.

Conclusions

For most patients analyzed in this study, prospective gating provided more accurate 4D MRI (95th percentile of deviation: <1.5?mm) than did retrospective sorting within a clinically feasible scan time (median: 5.9?min). The 4D MRI tended to take longer and to give larger sorting errors with deeper and irregular breathers.

SUBMITTER: Uh J

PROVIDER: S-EPMC7807601 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Effects of age-related breathing characteristics on the performance of four-dimensional magnetic resonance imaging reconstructed by prospective gating for radiation therapy planning.

Uh Jinsoo J Kadbi Mo M Hua Chia-Ho CH

Physics and imaging in radiation oncology 20190701

<h4>Background and purpose</h4>Four-dimensional magnetic resonance imaging (4D MRI) has advanced recently by incorporating prospective gating, but its performance on pediatric populations has not been investigated. This study aimed to determine the age-related performance of prospective gating, as compared with retrospective sorting.<h4>Materials and methods</h4>Prospectively gated 4D MRI scans were acquired on a motion phantom driven by real respiratory waveforms obtained from 23 pediatric and ...[more]

PMID: 33458284

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Project description:PURPOSE:To develop and validate a technique for radiation therapy gating using slow (?1 frame per second) magnetic resonance imaging (MRI) and a motion model. Proposed uses of the technique include radiation therapy gating using T2-weighted images and conducting additional imaging studies during gated treatments. METHODS AND MATERIALS:The technique uses a physiologically guided breathing motion model to interpolate deformed target position between 2-dimensional (2D) MRI images acquired every 1 to 3 seconds. The model is parameterized by a 1-dimensional respiratory bellows surrogate and is continuously updated with the most recently acquired 2D images. A phantom and 8 volunteers were imaged with a 0.35T MRI-guided radiation therapy system. A balanced steady-state free precession sequence with a 2D frame rate of 3 frames per second was used to evaluate the technique. The accuracy and beam-on positive predictive value (PPV) of the model-based gating decisions were evaluated using the gating decisions derived from imaging as a ground truth. A T2-weighted gating offline proof-of-concept study using a half-Fourier, single-shot, turbo-spin echo sequence is reported. RESULTS:Model-interpolated gating accuracy, beam-on PPV, and median absolute distances between model and image-tracked target centroids were, on average, 98.3%, 98.4%, and 0.33 mm, respectively, in the balanced steady-state free precession phantom studies and 93.7%, 92.1%, and 0.86 mm, respectively, in the volunteer studies. T2 model-interpolated gating in 6 volunteers yielded an average accuracy and PPV of 94.3% and 92.5%, respectively, and the mean absolute median distance between modeled and imaged target centroids was 0.86 mm. CONCLUSIONS:This work demonstrates the concept of model-interpolated gating for MRI-guided radiation therapy. The technique was found to be potentially sufficiently accurate for clinical use. Further development is needed to accommodate out-of-plane motion and the use of an internal MR-based respiratory surrogate.

Dataset Information

Effects of age-related breathing characteristics on the performance of four-dimensional magnetic resonance imaging reconstructed by prospective gating for radiation therapy planning.

Background and purpose

Materials and methods

Results

Conclusions

Publications

Effects of age-related breathing characteristics on the performance of four-dimensional magnetic resonance imaging reconstructed by prospective gating for radiation therapy planning.

Similar Datasets

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