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Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer.


ABSTRACT:

Background and purpose

Organ motion is a challenge during high-precision external beam radiotherapy in cervical cancer, and improved strategies for treatment adaptation and monitoring of target dose coverage are needed. This study evaluates a cone beam computed tomography (CBCT)-based approach.

Materials and methods

In twenty-three patients, individualized internal target volumes (ITVs) were generated from pre-treatment MRI and CT scans with full and empty bladders. The target volumes encompassed high-risk clinical target volume (CTV-T HR) (gross tumor volume?+?remaining cervix) and low risk (LR) CTV-T (CTV-T HR?+?uterus?+?parametriae?+?upper vagina). Volumetric Modulated Arc Therapy (VMAT) was used to deliver a dose of 45?Gy in 25 fractions. CBCTs were used for setup and for radiation therapists (RTTs) to evaluate the target coverage (inside/outside the planning target volume). CBCTs were reviewed offline. Estimates of the dose delivered with minimum (point) doses across all fractions to CTV-T HR (aim 42.75?Gy) and CTV-T LR (aim 40?Gy) were assessed. In patients with insufficient dose coverage, re-plans were generated based on previous imaging.

Results

Median (range) of the ITV-margins (mean of anterior-posterior margins) related to uterus and cervix was 1.2 (0.5-2.2 and 1.0-2.1) cm. RTTs were able to assess the target coverage in 90% of all CBCTs (505/563). With re-planning, one patient had considerable benefit (12.7?Gy increase of minimum dose) to CTV-T LR_vagina, four patients had improved dose to the CTV-T LR_uterus (1.2-1.8?Gy), and 3 patients did not benefit from re-planning.

Conclusions

Daily CBCT-based monitoring of target coverage by the RTTs has proven safe with limited workload. It allows for reduction in the treated volumes without compromising the target dose coverage.

SUBMITTER: Jensen NBK 

PROVIDER: S-EPMC7807672 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer.

Jensen Nina Boje Kibsgaard NBK   Assenholt Marianne Sanggaard MS   Fokdal Lars Ulrik LU   Vestergaard Anne A   Schouboe Annette A   Kjaersgaard Eva Bruun EB   Boejen Annette A   Nyvang Lars L   Lindegaard Jacob Christian JC   Tanderup Kari K  

Physics and imaging in radiation oncology 20181220


<h4>Background and purpose</h4>Organ motion is a challenge during high-precision external beam radiotherapy in cervical cancer, and improved strategies for treatment adaptation and monitoring of target dose coverage are needed. This study evaluates a cone beam computed tomography (CBCT)-based approach.<h4>Materials and methods</h4>In twenty-three patients, individualized internal target volumes (ITVs) were generated from pre-treatment MRI and CT scans with full and empty bladders. The target vol  ...[more]

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