Cone beam computed tomography-based monitoring and management of target and organ motion during external beam radiotherapy in cervical cancer.

ABSTRACT:

Background and purpose

Organ motion is a challenge during high-precision external beam radiotherapy in cervical cancer, and improved strategies for treatment adaptation and monitoring of target dose coverage are needed. This study evaluates a cone beam computed tomography (CBCT)-based approach.

Materials and methods

In twenty-three patients, individualized internal target volumes (ITVs) were generated from pre-treatment MRI and CT scans with full and empty bladders. The target volumes encompassed high-risk clinical target volume (CTV-T HR) (gross tumor volume + remaining cervix) and low risk (LR) CTV-T (CTV-T HR + uterus + parametriae + upper vagina). Volumetric Modulated Arc Therapy (VMAT) was used to deliver a dose of 45 Gy in 25 fractions. CBCTs were used for setup and fo

SUBMITTER: Jensen NBK 

PROVIDER: S-EPMC7807672 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature