Ontology highlight
ABSTRACT:
SUBMITTER: Patrick E
PROVIDER: S-EPMC7809035 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Patrick Ellis E Olah Marta M Taga Mariko M Klein Hans-Ulrich HU Xu Jishu J White Charles C CC Felsky Daniel D Agrawal Sonal S Gaiteri Chris C Chibnik Lori B LB Mostafavi Sara S Schneider Julie A JA Bennett David A DA Bradshaw Elizabeth M EM De Jager Philip L PL
Translational psychiatry 20210114 1
Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 540 subjects from two cohort studies of brain aging. Two of these transcriptional programs-modules 113 and 114-relate to the accumulation of β-amyloid ...[more]