Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors.
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ABSTRACT:
SUBMITTER: Iacobucci GJ
PROVIDER: S-EPMC7812756 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors.
Iacobucci Gary J GJ Wen Han H Helou Matthew M Liu Beiying B Zheng Wenjun W Popescu Gabriela K GK
Proceedings of the National Academy of Sciences of the United States of America 20210101 2
NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glutamate binding to glycine-bound receptors and subsequent constriction of the ligand-binding domain. Later, three short linkers transduce this movement to open the gate by mechanical pulling on transme ...[more]
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