Ontology highlight
ABSTRACT:
SUBMITTER: Luo Z
PROVIDER: S-EPMC7812788 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Luo Zhenwei Z Campos-Acevedo Adam A AA Lv Longfei L Wang Qinghua Q Ma Jianpeng J
Proceedings of the National Academy of Sciences of the United States of America 20210101 2
In this paper, we present a refinement method for cryo-electron microscopy (cryo-EM) single-particle reconstruction, termed as OPUS-SSRI (Sparseness and Smoothness Regularized Imaging). In OPUS-SSRI, spatially varying sparseness and smoothness priors are incorporated to improve the regularity of electron density map, and a type of real space penalty function is designed. Moreover, we define the back-projection step as a local kernel regression and propose a first-order method to solve the result ...[more]