Ontology highlight
ABSTRACT:
SUBMITTER: Lee DH
PROVIDER: S-EPMC7814060 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lee Dong Hoon DH Kim Go Woon GW Yoo Jung J Lee Sang Wu SW Jeon Yu Hyun YH Kim So Yeon SY Kang Hyeok Gu HG Kim Da-Hyun DH Chun Kyung-Hee KH Choi Junjeong J Kwon So Hee SH
Cell death & disease 20210118 1
Glioblastoma is the most lethal brain tumor and its pathogenesis remains incompletely understood. KDM4C is a histone H3K9 demethylase that contributes to epigenetic regulation of both oncogene and tumor suppressor genes and is often overexpressed in human tumors, including glioblastoma. However, KDM4C's roles in glioblastoma and the underlying molecular mechanisms remain unclear. Here, we show that KDM4C knockdown significantly represses proliferation and tumorigenesis of glioblastoma cells in v ...[more]