STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing.
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ABSTRACT:
SUBMITTER: Aoki K
PROVIDER: S-EPMC7817837 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing.
Aoki Kana K Harada Shota S Kawaji Keita K Matsuzawa Kenji K Uchida Seiichi S Ikenouchi Junichi J
Nature communications 20210120 1
The cytoplasm in mammalian cells is considered homogeneous. In this study, we report that the cytoplasmic fluidity is regulated in the blebbing cells; the cytoplasm of rapidly expanding membrane blebs is more disordered than the cytoplasm of retracting blebs. The increase of cytoplasmic fluidity in the expanding bleb is caused by a sharp rise in the calcium concentration. The STIM-Orai1 pathway regulates this rapid and restricted increase of calcium in the expanding blebs. Conversely, activated ...[more]
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