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Mild synthesis of isoxazoline derivatives via an efficient [4?+?1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

ABSTRACT: An efficient [4?+?1] annulation between ?-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.

SUBMITTER: Hua TB

PROVIDER: S-EPMC7822858 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides.

Hua Ting-Bi TB Liu Cheng-Xiong CX Hu Wei-Min WM Wang Long L Yang Qing-Qing QQ

Scientific reports 20210122 1

An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields. ...[more]

PMID: 33483530

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