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Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog.


ABSTRACT: Plasma neurofilament light chain (pNfL) concentration is a biomarker for neuroaxonal injury and degeneration and can be used to monitor response to treatment. Spontaneous canine neurodegenerative diseases are a valuable comparative resource for understanding similar human conditions and as large animal treatment models. The features of pNfL concentration in healthy dogs is not well established. We present data reporting basic pNfL concentration trends in the Labrador Retriever breed. Fifty-five Labrador Retrievers were enrolled. pNfL concentration was measured and correlated to age, sex, neuter status, height, weight, body mass index, and coat color. We found increased pNfL with age (P?

SUBMITTER: Perino J 

PROVIDER: S-EPMC7832257 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog.

Perino Jackie J   Patterson Margaret M   Momen Mehdi M   Borisova Mina M   Heslegrave Amanda A   Zetterberg Henrik H   Gruel Jordan J   Binversie Emily E   Baker Lauren L   Svaren John J   Sample Susannah J SJ  

Neuroscience letters 20201224


Plasma neurofilament light chain (pNfL) concentration is a biomarker for neuroaxonal injury and degeneration and can be used to monitor response to treatment. Spontaneous canine neurodegenerative diseases are a valuable comparative resource for understanding similar human conditions and as large animal treatment models. The features of pNfL concentration in healthy dogs is not well established. We present data reporting basic pNfL concentration trends in the Labrador Retriever breed. Fifty-five  ...[more]

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