Ontology highlight
ABSTRACT:
SUBMITTER: Voorhies K
PROVIDER: S-EPMC7833432 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Voorhies Kirsten K Sordillo Joanne E JE McGeachie Michael M Ampleford Elizabeth E Wang Alberta L AL Lasky-Su Jessica J Tantisira Kelan K Dahlin Amber A Kelly Rachel S RS Ortega Victor E VE Lutz Sharon M SM Wu Ann C AC
Journal of personalized medicine 20210119 1
An unaddressed and important issue is the role age plays in modulating response to short acting β2-agonists in individuals with asthma. The objective of this study was to identify whether age modifies genetic associations of single nucleotide polymorphisms (SNPs) with bronchodilator response (BDR) to β2-agonists. Using three cohorts with a total of 892 subjects, we ran a genome wide interaction study (GWIS) for each cohort to examine SNP by age interactions with BDR. A fixed effect meta-analysis ...[more]