Ontology highlight
ABSTRACT:
SUBMITTER: Duan QL
PROVIDER: S-EPMC3349771 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Duan Q L QL Du R R Lasky-Su J J Klanderman B J BJ Partch A B AB Peters S P SP Irvin C G CG Hanrahan J P JP Lima J J JJ Blake K V KV Liggett S B SB Litonjua A A AA Tantisira K G KG
The pharmacogenomics journal 20120103 2
A pro-asthmatic culture milieu and β2-agonist (isoproterenol) were previously shown to regulate the expression of select transcription factors (TFs) within human airway epithelial and smooth muscle cells. This study tests 1116 single-nucleotide polymorphisms (SNPs) across 98 of these TF genes for association with bronchodilator response (BDR) in asthma patients. Genotyping was conducted using the Illumina HumanHap550v3 Beadchip in 403 non-Hispanic White asthmatic children and their parents. SNPs ...[more]