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Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila.

ABSTRACT: Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.

SUBMITTER: Fan X

PROVIDER: S-EPMC7835053 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila.

Fan Xiaolan X Zeng Yao Y Fan Ziqiang Z Cui Liang L Song Wenhao W Wu Qi Q Gao Yue Y Yang Deying D Mao Xueping X Zeng Bo B Zhang Mingwang M Ni Qingyong Q Li Yan Y Wang Tao T Li Diyan D Yang Mingyao M

Aging 20201203 1

Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could ...[more]

PMID: 33291074

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