Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC7838801 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Guohui G Deng Liang L Huang Nan N Sun Fenyong F
Diseases (Basel, Switzerland) 20210113 1
Chemo and radiation therapies are the most commonly used therapies for cancer, but they can induce DNA damage, resulting in the apoptosis of host cells. DNA double-stranded breaks (DSBs) are the most lethal form of DNA damage in cells, which are constantly caused by a wide variety of genotoxic agents, both environmentally and endogenously. To maintain genomic integrity, eukaryotic organisms have developed a complex mechanism for the repair of DNA damage. Researches reported that many cellular lo ...[more]