Ontology highlight
ABSTRACT:
SUBMITTER: Mondal A
PROVIDER: S-EPMC7839547 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20201109 2
Alkynes are highly attractive motifs in organic synthesis due to their presence in natural products and bioactive molecules as well as their versatility in a plethora of subsequent transformations. A common procedure to insert alkynes into (hetero)arenes, such as the thiophenes studied herein, consists of a halogenation followed by a Sonogashira cross-coupling. The regioselectivity of this approach depends entirely on the halogenation step. Similarly, direct alkynylations of thiophenes have been ...[more]