Ontology highlight
ABSTRACT:
SUBMITTER: Jana J
PROVIDER: S-EPMC7839732 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Jana Jagannath J Weisz Klaus K
Chemistry (Weinheim an der Bergstrasse, Germany) 20201119 71
Multiple G-tracts within the promoter region of the c-myc oncogene may fold into various G-quadruplexes with the recruitment of different tracts and guanosine residues for the G-core assembly. Thermodynamic profiles for the folding of wild-type and representative truncated as well as mutated sequences were extracted by comprehensive DSC experiments. The unique G-quadruplex involving consecutive G-tracts II-V with formation of two one-nucleotide and one central two-nucleotide propeller loop, prev ...[more]