Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC7839785 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Zhou Yu Y Huo Shuaidong S Loznik Mark M Loznik Mark M Göstl Robert R Boersma Arnold J AJ Herrmann Andreas A
Angewandte Chemie (International ed. in English) 20201113 3
Ultrasound (US) produces cavitation-induced mechanical forces stretching and breaking polymer chains in solution. This type of polymer mechanochemistry is widely used for synthetic polymers, but not biomacromolecules, even though US is biocompatible and commonly used for medical therapy as well as in vivo imaging. The ability to control protein activity by US would thus be a major stepping-stone for these disciplines. Here, we provide the first examples of selective protein activation and deacti ...[more]