Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging.

ABSTRACT:

Background

The g-ratio, quantifying the comparative thickness of the myelin sheath encasing an axon, is a geometrical invariant that has high functional relevance because of its importance in determining neuronal conduction velocity. Advances in MRI data acquisition and signal modelling have put in vivo mapping of the g-ratio, across the entire white matter, within our reach. This capacity would greatly increase our knowledge of the nervous system: how it functions, and how it is impacted by disease.

New method

This is the second review on the topic of g-ratio mapping using MRI.

Results

This review summarizes the most recent developments in the field, while also providing methodological background pertinent to aggregate g-ratio weighted mapping, and discussing pitfall

SUBMITTER: Mohammadi S 

PROVIDER: S-EPMC7840525 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature