Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC7846603 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Park Spencer S Pascua Edward E Lindquist Kevin C KC Kimberlin Christopher C Deng Xiaodi X Mak Yvonne S L YSL Melton Zea Z Johnson Theodore O TO Lin Regina R Boldajipour Bijan B Abraham Robert T RT Pons Jaume J Sasu Barbra Johnson BJ Van Blarcom Thomas J TJ Chaparro-Riggers Javier J
Nature communications 20210129 1
Antibody-based therapeutics have experienced a rapid growth in recent years and are now utilized in various modalities spanning from conventional antibodies, antibody-drug conjugates, bispecific antibodies to chimeric antigen receptor (CAR) T cells. Many next generation antibody therapeutics achieve enhanced potency but often increase the risk of adverse events. Antibody scaffolds capable of exhibiting inducible affinities could reduce the risk of adverse events by enabling a transient suspensio ...[more]