Ontology highlight
ABSTRACT:
SUBMITTER: Luther PK
PROVIDER: S-EPMC3136262 | biostudies-other | 2011 Jul
REPOSITORIES: biostudies-other
Luther Pradeep K PK Winkler Hanspeter H Taylor Kenneth K Zoghbi Maria E ME Craig Roger R Padrón Raúl R Squire John M JM Squire John M JM Liu Jun J
Proceedings of the National Academy of Sciences of the United States of America 20110624 28
Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studies suggest that MyBP-C could regulate contraction in a unique way--by bridging thick and thin filaments--but there has been no evidence for this in vivo. Here we use electron tomography of exceptionally well p ...[more]