Ontology highlight
ABSTRACT:
SUBMITTER: Lee SB
PROVIDER: S-EPMC7862247 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Lee Su Been SB Park Jihyun J Kwak Yongdo Y Park Young-Un YU Nhung Truong Thi My TTM Suh Bo Kyoung BK Woo Youngsik Y Suh Yeongjun Y Cho Eunbyul E Cho Sehyung S Park Sang Ki SK
Translational psychiatry 20210204 1
Disrupted-in-schizophrenia 1 (DISC1) is a scaffold protein that has been implicated in multiple mental disorders. DISC1 is known to regulate neuronal proliferation, signaling, and intracellular calcium homeostasis, as well as neurodevelopment. Although DISC1 was linked to sleep-associated behaviors, whether DISC1 functions in the circadian rhythm has not been determined yet. In this work, we revealed that Disc1 expression exhibits daily oscillating pattern and is regulated by binding of circadia ...[more]