Ontology highlight
ABSTRACT:
SUBMITTER: Hong C
PROVIDER: S-EPMC7864924 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nature communications 20210205 1
Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain's ability to control sleep-wake cycles. Current therapies are limited to the management of symptoms with modest effectiveness and substantial adverse effects. Agonists of the orexin receptor 2 (OX<sub>2</sub>R) have shown promise as novel therapeutics that directly target the pathophysiology of the disease. However, identification of drug-like OX<sub>2</sub>R agonists has proven difficult. Here we report cryo-elect ...[more]