Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC7868706 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Role of ALDH2 in Hepatic Disorders: Gene Polymorphism and Disease Pathogenesis.
Wang Qiaoling Q Chang Binxia B Li Xiaoyan X Zou Zhengsheng Z
Journal of clinical and translational hepatology 20210104 1
Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease. <i>ALDH2</i> gene mutations exist in about 8% of the world's population, with the incidence reaching 45% in East Asia. The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde, facilitating the progression of other liver diseases, including non-alcoholic fatty liver diseases, viral hepatitis and hepatocellular carcinoma, ...[more]
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