Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment.

ABSTRACT:

Aim

To examine associations between the deep medullary vein white matter injury global severity scoring system and neurodevelopmental impairment.

Methods

This is a prospective observational cohort study of infants born at ≥32 weeks, diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first month of life. Developmental testing was performed using validated measures for early, preschool, and school-age follow-up.

Results

Nineteen (37%) patients had major neurodevelopmental impairment. Global severity score was higher among patients with neurodevelopmental impairment (21.6 vs 13.4, P = .04). Overall, 78% of patients with epilepsy had neurodevelopmental impairment. A greater degree of asymmetry with right-sided injury predominance wa

SUBMITTER: Benninger KL 

PROVIDER: S-EPMC7874519 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature