Ontology highlight
ABSTRACT:
SUBMITTER: Li T
PROVIDER: S-EPMC7887217 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Li Tingting T Wang Xian X Ju Enguo E da Silva Suzane Ramos SR Chen Luping L Zhang Xinquan X Wei Shan S Gao Shou-Jiang SJ
Nature communications 20210216 1
mTORC1, a central controller of cell proliferation in response to growth factors and nutrients, is dysregulated in cancer. Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1). Because cancer cells often encounter low levels of nutrients, an alternative mechanism might exist to regulate CASTOR1 expression. Here we show K29-linked polyubiquitination and degradation of CASTOR1 by E3 ubiquitin ligase RNF167. Furthermore, ...[more]