Ontology highlight
ABSTRACT:
SUBMITTER: Beshnova D
PROVIDER: S-EPMC7887928 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Beshnova Daria D Ye Jianfeng J Onabolu Oreoluwa O Moon Benjamin B Zheng Wenxin W Fu Yang-Xin YX Fu Yang-Xin YX Brugarolas James J Lea Jayanthi J Li Bo B
Science translational medicine 20200801 557
The adaptive immune system recognizes tumor antigens at an early stage to eradicate cancer cells. This process is accompanied by systemic proliferation of the tumor antigen-specific T lymphocytes. While detection of asymptomatic early-stage cancers is challenging due to small tumor size and limited somatic alterations, tracking peripheral T cell repertoire changes may provide an attractive solution to cancer diagnosis. Here, we developed a deep learning method called DeepCAT to enable de novo pr ...[more]