Ontology highlight
ABSTRACT:
SUBMITTER: Reintjens NRM
PROVIDER: S-EPMC7894537 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Reintjens Niels R M NRM Tondini Elena E Vis Christopher C McGlinn Toroa T Meeuwenoord Nico J NJ Hogervorst Tim P TP Overkleeft Herman S HS Filippov Dmitri V DV van der Marel Gijsbert A GA Ossendorp Ferry F Codée Jeroen D C JDC
Chembiochem : a European journal of chemical biology 20201023 2
Mannose-6-phosphate (M6P) is recognized by the mannose-6-phosphate receptor and plays an important role in the transport of cargo to the endosomes, making it an attractive tool to improve endosomal trafficking of vaccines. We describe herein the assembly of peptide antigen conjugates carrying clusters of mannose-6-C-phosphonates (M6Po). The M6Po's are stable M6P mimics that are resistant to cleavage of the phosphate group by endogenous phosphatases. Two different strategies for the incorporation ...[more]