Ontology highlight
ABSTRACT:
SUBMITTER: Skvortsov S
PROVIDER: S-EPMC7903656 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Skvortsov Sergej S Skvortsova Ira-Ida II Tang Dean G DG Dubrovska Anna A
Stem cells (Dayton, Ohio) 20180827 10
Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types. PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition and evolution of the cancer genome and by epigenetic mechanisms that result in subclonal cellular differentiation. The process of tumor cell differentiation is initiated from a population of prostate cancer stem cells (PCSCs) that possess many phenotypic and functional properties of normal stem cells. Since the in ...[more]