Dataset Information
Genetic association testing using the GENESIS R/Bioconductor package.
Ontology highlight
ABSTRACT: Summary
The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to perform various single- and aggregate-variant association tests using genotype data stored in GDS format. GENESIS implements highly flexible mixed models, allowing for different link functions, multiple variance components and phenotypic heteroskedasticity. GENESIS integrates cohesively with other R/Bioconductor packages to build a complete genomic analysis workflow entirely within the R environment.Availability and implementation
https://bioconductor.org/packages/GENESIS; vignettes included.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Gogarten SM
PROVIDER: S-EPMC7904076 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic association testing using the GENESIS R/Bioconductor package.
Bioinformatics (Oxford, England) 20191201 24
<h4>Summary</h4>The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays and sequencing. We developed GENESIS to perform various single- and aggregate-variant association tests using genotype data stored in GDS format. GENESIS implements highly flexible mixed models, allowing for different link functions, multiple variance components and phenotypic heteroskedasticity. GENESIS integrates cohesively with other R/Bioconductor packages to bu ...[more]
