Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC7906602 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Liu Qiuying Q Chen Xiaoli X Novak Mariah K MK Zhang Shaojie S Hu Wenqian W
eLife 20210218
The regulation of stem cell fate is poorly understood. Genetic studies in <i>Caenorhabditis elegans</i> lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA controls the pluripotency and differentiation of stem cells. Although let-7-microRNA-mediated inhibition of Trim71 promotes differentiation, whether and how Trim71 regulates pluripotency and inhibits the let-7 microRNA are still unknown. Here, we ...[more]