Dataset Information

Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection.

ABSTRACT:

Objective

Serious bacterial infection (SBI) remains an important cause of morbidity and mortality in preterm infants. The objective of this study was to evaluate the dynamically increased value of the red cell distribution width (RDW) in the diagnosis of SBI.

Methods

This retrospective study enrolled 334 preterm infants with birth weight less than 1500?g. The initial RDW and the maximum value of RDW during hospitalization were extracted from the MIMIC-III database (version 1.4). Infants were categorized into four groups according to baseline RDW value and ?RDW (?RDW?=?RDW at maximum- RDW at baseline). Logistic regression analysis was used to assess the risk of developing SBI in each group. A receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of RDW at baseline alone, ?RDW alone, and in combination.

Results

Infants with increased RDW at baseline (>?17%) and ?RDW >?2% exhibited the highest risk of developing SBI, whereas the patients with normal RDW level at baseline (? 17%) and ?RDW?2% (the reference group) had the lowest risk. This association remained unaltered even after adjustment in multivariable models. Basing on ROC curve analysis, the area under the curve predicted by the combination of RDW at baseline and ?RDW for SBI was 0.81 (95% CI, 0.76-0.87). Sensitivity and specificity were 78.16 and 72.47% respectively.

Conclusions

We observed that combination of elevated RDW at baseline and dynamic increases during hospitalization is significantly associated with SBI. Therefore, that combination could be a promising independent diagnostic indicator of SBI in newborns.

SUBMITTER: Guo BF

PROVIDER: S-EPMC7913272 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection.

Guo Bin-Fang BF Sun Su-Zhen SZ

Italian journal of pediatrics 20210227 1

<h4>Objective</h4>Serious bacterial infection (SBI) remains an important cause of morbidity and mortality in preterm infants. The objective of this study was to evaluate the dynamically increased value of the red cell distribution width (RDW) in the diagnosis of SBI.<h4>Methods</h4>This retrospective study enrolled 334 preterm infants with birth weight less than 1500 g. The initial RDW and the maximum value of RDW during hospitalization were extracted from the MIMIC-III database (version 1.4). I ...[more]

PMID: 33640017

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Dataset Information

Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection.

Objective

Methods

Results

Conclusions

Publications

Diagnostic accuracy of a dynamically increased red blood cell distribution width in very low birth weight infants with serious bacterial infection.

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