Dataset Information

Novel Surfactant-Free Water Dispersion Technique of TiO₂ NPs Using Focused Ultrasound System.

ABSTRACT: Titanium dioxide (TiO₂) nanoparticles are used in a wide variety of products, such as renewable energy resources, cosmetics, foods, packaging materials, and inks. However, large quantities of surfactants are used to prepare waterborne TiO₂ nanoparticles with long-term dispersion stability, and very few studies have investigated the development of pure water dispersion technology without the use of surfactants and synthetic auxiliaries. This study investigated the use of focused ultrasound to prepare surfactant-free waterborne TiO₂ nanoparticles to determine the optimal conditions for dispersion of TiO₂ nanoparticles in water. Under 395-400 kHz and 100-105 W conditions, 1 wt% TiO₂ colloids were prepared. Even in the absence of a surfactant, in the water dispersion state, the nanoparticles were dispersed with a particle size distribution of ?100 nm and did not re-agglomerate for up to 30 days, demonstrating their excellent dispersion stability.

SUBMITTER: Hwangbo SA

PROVIDER: S-EPMC7915381 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Novel Surfactant-Free Water Dispersion Technique of TiO2 NPs Using Focused Ultrasound System.

Hwangbo Seon Ae SA Kwak Minjeong M Kim Jaeseok J Lee Tae Geol TG

Nanomaterials (Basel, Switzerland) 20210208 2

Titanium dioxide (TiO2) nanoparticles are used in a wide variety of products, such as renewable energy resources, cosmetics, foods, packaging materials, and inks. However, large quantities of surfactants are used to prepare waterborne TiO2 nanoparticles with long-term dispersion stability, and very few studies have investigated the development of pure water dispersion technology without the use of surfactants and synthetic auxiliaries. This study investigated the use of foc ...[more]

PMID: 33567644

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Project description:BACKGROUND:MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance. METHODS:A hardware and software package was developed that includes closed-loop feedback controlled thermometry code and CAD drawings for a therapy table designed for a preclinical MRI scanner. For thermal treatments, the modular software uses a proportional integral derivative controller to maintain a precise focal temperature rise in the target given input from MR phase images obtained concurrently. The software computes the required voltage output and transmits it to a FUS transducer that is embedded in the delivery table within the magnet bore. The delivery table holds the FUS transducer, a small animal and its monitoring equipment, and a transmit/receive RF coil. The transducer is coupled to the animal via a water bath and is translatable in two dimensions from outside the magnet. The transducer is driven by a waveform generator and amplifier controlled by real-time software in Matlab. MR acoustic radiation force imaging is also implemented to confirm the position of the focus for mechanical and thermal treatments. RESULTS:The system was validated in tissue-mimicking phantoms and in vivo during murine tumor hyperthermia treatments. Sonications were successfully controlled over a range of temperatures and thermal doses for up to 20 min with minimal temperature overshoot. MR thermometry was validated with an optical temperature probe, and focus visualization was achieved with acoustic radiation force imaging. CONCLUSIONS:We developed an MRgFUS platform for small-animal treatments that robustly delivers accurate, precise, and controllable sonications over extended time periods. This system is an open source and could increase the availability of low-cost small-animal systems to interdisciplinary researchers seeking to develop new MRgFUS applications and technology.

Dataset Information

Novel Surfactant-Free Water Dispersion Technique of TiO₂ NPs Using Focused Ultrasound System.

Publications

Novel Surfactant-Free Water Dispersion Technique of TiO<sub>2</sub> NPs Using Focused Ultrasound System.

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