Dataset Information

3D Structural Insights into ?-Glucans and Their Binding Proteins.

ABSTRACT: ?(1,3)-glucans are a component of fungal and plant cell walls. The ?-glucan of pathogens is recognized as a non-self-component in the host defense system. Long ?-glucan chains are capable of forming a triple helix structure, and the tertiary structure may profoundly affect the interaction with ?-glucan-binding proteins. Although the atomic details of ?-glucan binding and signaling of cognate receptors remain mostly unclear, X-ray crystallography and NMR analyses have revealed some aspects of ?-glucan structure and interaction. Here, we will review three-dimensional (3D) structural characteristics of ?-glucans and the modes of interaction with ?-glucan-binding proteins.

SUBMITTER: Manabe N

PROVIDER: S-EPMC7915573 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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3D Structural Insights into β-Glucans and Their Binding Proteins.

Manabe Noriyoshi N Yamaguchi Yoshiki Y

International journal of molecular sciences 20210204 4

β(1,3)-glucans are a component of fungal and plant cell walls. The β-glucan of pathogens is recognized as a non-self-component in the host defense system. Long β-glucan chains are capable of forming a triple helix structure, and the tertiary structure may profoundly affect the interaction with β-glucan-binding proteins. Although the atomic details of β-glucan binding and signaling of cognate receptors remain mostly unclear, X-ray crystallography and NMR analyses have revealed some aspects of β-g ...[more]

PMID: 33557270

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Dataset Information

3D Structural Insights into ?-Glucans and Their Binding Proteins.

Publications

3D Structural Insights into β-Glucans and Their Binding Proteins.

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