Ontology highlight
ABSTRACT:
SUBMITTER: Kannt A
PROVIDER: S-EPMC7918612 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kannt Aimo A Rajagopal Sridharan S Hallur Mahanandeesha S MS Swamy Indu I Kristam Rajendra R Dhakshinamoorthy Saravanakumar S Czech Joerg J Zech Gernot G Schreuder Herman H Ruf Sven S
Molecules (Basel, Switzerland) 20210213 4
Nicotinamide-<i>N</i>-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from <i>S</i>-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expression in several cancer cell lines has been widely discussed in the literature, and recent work established a link between NNMT expression and metabolic diseases. Here we describe our approach to identify potent small molecule ...[more]