Dataset Information

Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria.

ABSTRACT:

Background

The molecular diagnosis of gliomas such as isocitrate dehydrogenase (IDH) status (wild-type [wt] or mutation [mut]) is especially important in the 2016 World Health Organization (WHO) classification. Positron emission tomography (PET) has afforded molecular and metabolic diagnostic imaging. The present study aimed to define the interrelationship between the 2016 WHO classification of gliomas and the integrated data from PET images using multiple tracers, including ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG), ¹¹C-methionine (¹¹C-MET), ¹⁸F-fluorothymidine (¹⁸F-FLT), and ¹⁸F-fluoromisonidazole (¹⁸F-FMISO).

Methods

This retrospective, single-center study comprised 113 patients with newly diagnosed glioma based on the 2016 WHO criteria. Patients were divided into 4 glioma subtypes (Mut, Codel, Wt, and glioblastoma multiforme [GBM]). Tumor standardized uptake value (SUV) divided by mean normal cortical SUV (tumor-normal tissue ratio [TNR]) was calculated for ¹⁸F-FDG, ¹¹C-MET, and ¹⁸F-FLT. Tumor-blood SUV ratio (TBR) was calculated for ¹⁸F-FMISO. To assess the diagnostic accuracy of PET tracers in distinguishing glioma subtypes, a comparative analysis of TNRs and TBR as well as the metabolic tumor volume (MTV) were calculated by Scheffe's multiple comparison procedure for each PET tracer following the Kruskal-Wallis test.

Results

The differences in mean ¹⁸F-FLT TNR and ¹⁸F-FMISO TBR were significant between GBM and other glioma subtypes (P < .001). Regarding the comparison between Gd-T1WI volumes and ¹⁸F-FLT MTVs or ¹⁸F-FMISO MTVs, we identified significant differences between Wt and Mut or Codel (P < .01).

Conclusion

Combined administration of 4 PET tracers might aid in the preoperative differential diagnosis of gliomas according to the 2016 WHO criteria.

SUBMITTER: Miyake K

PROVIDER: S-EPMC7920529 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria.

Miyake Keisuke K Suzuki Kenta K Ogawa Tomoya T Ogawa Daisuke D Hatakeyama Tetsuhiro T Shinomiya Aya A Kudomi Nobuyuki N Yamamoto Yuka Y Nishiyama Yoshihiro Y Tamiya Takashi T

Neuro-oncology advances 20201207 1

<h4>Background</h4>The molecular diagnosis of gliomas such as isocitrate dehydrogenase (IDH) status (wild-type [wt] or mutation [mut]) is especially important in the 2016 World Health Organization (WHO) classification. Positron emission tomography (PET) has afforded molecular and metabolic diagnostic imaging. The present study aimed to define the interrelationship between the 2016 WHO classification of gliomas and the integrated data from PET images using multiple tracers, including <sup>18</sup ...[more]

PMID: 33681765

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Dataset Information

Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria.

Background

Methods

Results

Conclusion

Publications

Multiple positron emission tomography tracers for use in the classification of gliomas according to the 2016 World Health Organization criteria.

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