High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity.

ABSTRACT:

Background

Cell division cycle-associated 7 (CDCA7), as a member of the cell division cycle associated family, was reported to be aberrantly expressed in both solid tumors and hematological tumors, suggesting its essential role in promoting tumorigenesis. Hence, we aimed to explore its comprehensive roles of overall survival (OS) in clear cell renal cell carcinoma (ccRCC) and emphasize its associations with immunity.

Methods

The RNA sequencing data and corresponding clinical information were downloaded from The Cancer Genome Atlas (TCGA) database. Gene set enrichment analysis (GSEA) was adopted to explore CDCA7 associated signaling pathways. Univariate and multivariate Cox regression analyses were carried out to assess independent prognostic factors. Furthermore, roles of CDCA7 in human immunity were also investigated.

Results

Our results suggested that CDCA7 was overexpressed in ccRCC and its elevated expression was related to shorter OS (P?ConclusionsCDCA7 could serve as an independent prognostic factor for ccRCC and it was closely related to MSI, TMB, and immunity.

SUBMITTER: Liu S 

PROVIDER: S-EPMC7923626 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature