Ontology highlight
ABSTRACT: Objective
To examine the pain-reducing effects of intra-articular oxygen-ozone (O2O3) injections and mechanical focal vibration (mFV) versus O2O3 injections alone in patients with knee osteoarthritis.Methods
Patients with chronic pain (>6 weeks) due to knee osteoarthritis (II-III on the Kellgren-Lawrence scale) were consecutively enrolled and divided into two groups: O2O3 (n?=?25) and O2O3-mFV (n?=?24). The visual analog scale (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Medical Research Council (MRC) Manual Muscle Testing scale were administered at baseline (before treatment), after 3 weeks of treatment, and 1 month after the end of treatment. Patients received three once-weekly intra-articular injections of O2O3 into the knee (20?mL O3, 20??g/mL). The O2O3-mFV group also underwent nine sessions of mFV (three sessions per week).Results
The VAS score, KOOS, and MRC score were significantly better in the O2O3-mFV than O2O3 group. The within-group analysis showed that all scores improved over time compared with baseline and were maintained even 1 month after treatment. No adverse events occurred.Conclusion
An integrated rehabilitation protocol involving O2O3 injections and mFV for 3 weeks reduces pain, increases autonomy in daily life activities, and strengthens the quadriceps femoris.
SUBMITTER: Paolucci T
PROVIDER: S-EPMC7923992 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Paolucci Teresa T Agostini Francesco F Bernetti Andrea A Paoloni Marco M Mangone Massimiliano M Santilli Valter V Pezzi Letizia L Bellomo Rosa Grazia RG Saggini Raoul R
The Journal of international medical research 20210201 2
<h4>Objective</h4>To examine the pain-reducing effects of intra-articular oxygen-ozone (O<sub>2</sub>O<sub>3</sub>) injections and mechanical focal vibration (mFV) versus O<sub>2</sub>O<sub>3</sub> injections alone in patients with knee osteoarthritis.<h4>Methods</h4>Patients with chronic pain (>6 weeks) due to knee osteoarthritis (II-III on the Kellgren-Lawrence scale) were consecutively enrolled and divided into two groups: O<sub>2</sub>O<sub>3</sub> (n = 25) and O<sub>2</sub>O<sub>3</sub>-mFV ...[more]