Human molecular evolutionary rate, time dependency and transient polymorphism effects viewed through ancient and modern mitochondrial DNA genomes.
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ABSTRACT:
SUBMITTER: Cabrera VM
PROVIDER: S-EPMC7930196 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Human molecular evolutionary rate, time dependency and transient polymorphism effects viewed through ancient and modern mitochondrial DNA genomes.
Scientific reports 20210303 1
Human evolutionary genetics gives a chronological framework to interpret the human history. It is based on the molecular clock hypothesis that suppose a straightforward relationship between the mutation rate and the substitution rate with independence of other factors as demography dynamics. Analyzing ancient and modern human complete mitochondrial genomes we show here that, along the time, the substitution rate can be significantly slower or faster than the average germline mutation rate confir ...[more]
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