ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.
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ABSTRACT:
SUBMITTER: Katsurahara K
PROVIDER: S-EPMC7935785 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.
Katsurahara Keita K Shiozaki Atsushi A Kosuga Toshiyuki T Shimizu Hiroki H Kudou Michihiro M Arita Tomohiro T Konishi Hirotaka H Komatsu Shuhei S Kubota Takeshi T Fujiwara Hitoshi H Okamoto Kazuma K Kishimoto Mitsuo M Konishi Eiichi E Otsuji Eigo E
Cancer science 20210122 3
The function of ANO9 in gastrointestinal cancer remains unclear. We investigated the biological behaviors and clinical prognostic values of ANO9 in gastric cancer (GC). Knockdown experiments were performed on human GC cell lines using ANO9 siRNA. Eighty-four primary tissue samples from patients with advanced GC were examined immunohistochemically (IHC). Knockdown of ANO9 reduced the progression of cancer cells in MKN7 and MKN74 cells. A microarray analysis revealed that ANO9 regulated PD-L2 via ...[more]
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