Ontology highlight
ABSTRACT:
SUBMITTER: Lei Y
PROVIDER: S-EPMC7947218 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Frontiers in cellular and infection microbiology 20210225
<i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) secretes numerous proteins to interfere with host immune response for its long-term survival. As one of the top abundant <i>M.tb</i> secreted proteins, Rv3722c was found to be essential for bacilli growth. However, it remains elusive how this protein interferes with the host immune response and regulates <i>M.tb</i> survival. Here, we confirmed that Rv3722c interacted with host TRAF3 to promote <i>M.tb</i> replication in macrophages. Knock-down of ...[more]