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Prediction of the Impact of Nozzle Geometry on Spray Characteristics.

ABSTRACT: In the present paper, the formation and development of cavitation inside the nozzle of an atomizer with different geometrical characteristics have been studied numerically. Different shapes of inlet nozzles and different nozzle-length-to-diameter ratios have been investigated. The developed model has been built as a three-dimensional (3D) one, where the turbulence is modeled considering large eddy simulation. The obtained computational results showed good agreement with the reported experimental results. It has been found that the occurrence of cavitation depends on the amount of energy needed to overcome the viscosity and friction between the liquid layers. The mass flowing through the nozzle decreases with increasing cavitation. The intensity of cavitation depends on the nozzle entrance shape. Sharp edges cause cavitation to occur early in the nozzle, followed by an inclined shape, and then the curved entrance. The dissipative energy in the cavitation and bubble collapse result in an increase in the turbulent kinetic energy of the issuing liquid. This causes more liquid disintegration, leading to larger spray volume and smaller droplet size. The obtained results for spray droplet size distribution have been compared with experimental data developed by other researchers, and a good agreement has also been found.

SUBMITTER: Mohamed MAE

PROVIDER: S-EPMC7948222 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Prediction of the Impact of Nozzle Geometry on Spray Characteristics.

Mohamed Mahmoud Abd El-Aziz MAE Abdel Hameed Hesham El-Sayed HE Shaltout Ramy Elsayed RE El-Salmawy Hafez Abdel Aal HAA

ACS omega 20210222 9

In the present paper, the formation and development of cavitation inside the nozzle of an atomizer with different geometrical characteristics have been studied numerically. Different shapes of inlet nozzles and different nozzle-length-to-diameter ratios have been investigated. The developed model has been built as a three-dimensional (3D) one, where the turbulence is modeled considering large eddy simulation. The obtained computational results showed good agreement with the reported experimental ...[more]

PMID: 33718712

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Project description:In a spray drying operation, a two-fluid nozzle (2FN) with a single channel is commonly used for atomizing the feed solution. However, the less commonly used three-fluid nozzle (3FN) has two separate channels, which allow spray drying of materials in two incompatible solution systems. Although amorphous solid dispersions (ASDs) prepared using a 3FN have been reported to deliver comparable drug dissolution performance relative to those prepared using a 2FN, few studies have systematically examined the effect of 3FN on the physical stability. Therefore, the goal of this work is to systematically study the physical stability of ASDs that are spray-dried using a 3FN compared to those prepared using the traditional 2FN. For the 2FN, a single solution of naproxen and polyvinylpyrrolidone (PVP) was prepared in a mixture of acetone and water at a 1:1 volume ratio because 2FN allows for only one solution inlet. For the 3FN, naproxen and PVP were dissolved individually in acetone and water, respectively, because 3FN allows simultaneous entry of two solutions. Upon storage of the formulated ASDs at different humidity levels (25%, 55% and 75% RH), naproxen crystallized more quickly from the 3FN ASDs as compared with the 2FN ASDs. 3FN ASDs crystallized after 5 days of storage at all conditions, whereas 2FN ASDs did not crystallize even at 55% RH for two months. This relatively higher crystallization tendency of 3FN ASDs was attributed to the inhomogeneity of drug and polymers as identified by the solid-state Nuclear Magnetic Resonance findings, specifically due to poor mixing of water- and acetone-based solutions at the 3FN nozzle. When only acetone was used as a solvent to prepare drug-polymer solutions for 3FN, the formulated ASD was found to be stable for >3 months of storage (at 75% RH), which suggests that instability of the 3FN ASD was due to the insufficient mixing of water and acetone solutions. This study provides insights into the effects of solvent and nozzle choices on the physical stability of spray-dried ASDs.

Dataset Information

Prediction of the Impact of Nozzle Geometry on Spray Characteristics.

Publications

Prediction of the Impact of Nozzle Geometry on Spray Characteristics.

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