Unknown

Dataset Information

0

Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection.


ABSTRACT: Considerable concerns relating to the duration of protective immunity against severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) exist, with evidence of antibody titers declining rapidly after infection and reports of reinfection. Here, we monitor the antibody responses against SARS-CoV-2 receptor-binding domain (RBD) for up to 6 months after infection. While antibody titers are maintained, ∼13% of the cohort's neutralizing responses return to background. However, encouragingly, in a selected subset of 13 participants, 12 have detectable RBD-specific memory B cells and these generally are increasing out to 6 months. Furthermore, we are able to generate monoclonal antibodies with SARS-CoV-2 neutralizing capacity from these memory B cells. Overall, our study suggests that the loss of neutralizing antibodies in plasma may be countered by the maintenance of neutralizing capacity in the memory B cell repertoire.

SUBMITTER: Abayasingam A 

PROVIDER: S-EPMC7955929 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-BSST379 | biostudies-other
| S-EPMC7219369 | biostudies-literature
| S-EPMC8387217 | biostudies-literature
| EGAS00001004412 | EGA
| S-EPMC8646652 | biostudies-literature
| S-EPMC8212047 | biostudies-literature
| EMPIAR-10951 | biostudies-other
| EMPIAR-10952 | biostudies-other
| S-EPMC8100443 | biostudies-literature
| S-EPMC7952403 | biostudies-literature