Unknown

Dataset Information

0

Overcoming the challenges associated with CD3+ T-cell redirection in cancer.


ABSTRACT: The development of bispecific antibodies that redirect the cytotoxic activity of CD3+ T cells to tumours is a promising immunotherapeutic strategy for the treatment of haematological malignancies and solid cancers. Since the landmark FDA approval at the end of 2014 of the anti-CD3 × anti-CD19 bispecific antibody blinatumomab (Blincyto®) for the treatment of relapsed/refractory B-cell acute lymphoblastic leukaemia, ~100 clinical trials investigating the safety and efficacy of CD3+ bispecific T-cell redirectors for cancer have been initiated. However, despite early success, numerous challenges pertaining to CD3+ T-cell redirection in the context of cancer exist, including the recruitment of counterproductive CD3+ T-cell subsets, the release of systemic cytokines, the expansion of immune checkpoint molecules, the presence of an immunosuppressive tumour microenvironment, tumour antigen loss/escape, on-target off-tumour toxicity and suboptimal potency. The aim of the present review is to discuss novel approaches to overcome the key challenges associated with CD3+ bispecific T-cell redirection in order to achieve an optimal balance of anti-tumour activity and safety.

SUBMITTER: Singh A 

PROVIDER: S-EPMC7960983 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7829968 | biostudies-literature
| S-EPMC8507531 | biostudies-literature
| S-EPMC6436848 | biostudies-literature
| S-EPMC8228580 | biostudies-literature
| S-EPMC5464651 | biostudies-literature
| S-EPMC8654168 | biostudies-literature
| S-EPMC7264144 | biostudies-literature
| S-EPMC10000604 | biostudies-literature
| S-EPMC4779434 | biostudies-literature
| S-EPMC5384386 | biostudies-literature