Unknown

Dataset Information

0

CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids.


ABSTRACT: The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.

SUBMITTER: Link A 

PROVIDER: S-EPMC8027949 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5800953 | biostudies-literature
| S-EPMC5587210 | biostudies-literature
| S-EPMC4866599 | biostudies-literature
| S-EPMC3365512 | biostudies-literature
| S-EPMC1868422 | biostudies-literature
| S-EPMC8346209 | biostudies-literature
| S-EPMC10107894 | biostudies-literature
| S-EPMC7319995 | biostudies-literature
| S-EPMC8150111 | biostudies-literature
| S-EPMC4264008 | biostudies-other