Dataset Information

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

ABSTRACT: Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.

SUBMITTER: Roark RS

PROVIDER: S-EPMC8040783 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

Roark Ryan S RS Li Hui H Williams Wilton B WB Chug Hema H Mason Rosemarie D RD Gorman Jason J Wang Shuyi S Lee Fang-Hua FH Rando Juliette J Bonsignori Mattia M Hwang Kwan-Ki KK Saunders Kevin O KO Wiehe Kevin K Moody M Anthony MA Hraber Peter T PT Wagh Kshitij K Giorgi Elena E EE Russell Ronnie M RM Bibollet-Ruche Frederic F Liu Weimin W Connell Jesse J Smith Andrew G AG DeVoto Julia J Murphy Alexander I AI Smith Jessica J Ding Wenge W Zhao Chengyan C Chohan Neha N Okumura Maho M Rosario Christina C Ding Yu Y Lindemuth Emily E Bauer Anya M AM Bar Katharine J KJ Ambrozak David D Chao Cara W CW Chuang Gwo-Yu GY Geng Hui H Lin Bob C BC Louder Mark K MK Nguyen Richard R Zhang Baoshan B Lewis Mark G MG Raymond Donald D DD Doria-Rose Nicole A NA Schramm Chaim A CA Douek Daniel C DC Roederer Mario M Kepler Thomas B TB Kelsoe Garnett G Mascola John R JR Kwong Peter D PD Korber Bette T BT Harrison Stephen C SC Haynes Barton F BF Hahn Beatrice H BH Shaw George M GM

Science (New York, N.Y.) 20201119 6525

Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertio ...[more]

PMID: 33214287

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Dataset Information

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

Publications

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.

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