Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches.

ABSTRACT: Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell's proliferation and metastasis. The liver tumor microenvironment contains the non-parenchymal cells with supportive or inhibitory effects on the cancerous phenotype of HCC. Several signaling pathways are dis-regulated in HCC and cause uncontrolled cell propagation, metastasis, and recurrence of liver carcinoma cells. Recent studies have established new approaches for the prevention and treatment of HCC using small molecules. Small molecules are compounds with a low molecular weight that usually inhibit the specific targets in signal transduction pathways. These components can induce cell

SUBMITTER: Farzaneh Z 

PROVIDER: S-EPMC8045321 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature