Ontology highlight
ABSTRACT:
SUBMITTER: Dugina V
PROVIDER: S-EPMC8068389 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Dugina Vera V Shagieva Galina G Novikova Mariya M Lavrushkina Svetlana S Sokova Olga O Kireev Igor I Kopnin Pavel P
Molecules (Basel, Switzerland) 20210408 8
We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic actin acts as a tumor suppressor, whereas γ-cytoplasmic actin enhances malignant features of tumor cells. The distinct participation of each cytoplasmic actin in the cell cycle driving was also observed. The goal of this study was to describe the diverse roles of cytoplasmic actins in the progression of chromosomal instability of MDA-MB-231 basal-like human c ...[more]