Ontology highlight
ABSTRACT:
SUBMITTER: Huang M
PROVIDER: S-EPMC8081665 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Huang Menghang M Zhang Xiaoxiao X Toh Gee Ann GA Gong Qin Q Wang Jia J Han Zhifu Z Wu Bin B Zhong Franklin F Chai Jijie J
Nature 20210317 7856
Nucleotide-binding domain, leucine-rich repeat receptors (NLRs) mediate innate immunity by forming inflammasomes. Activation of the NLR protein NLRP1 requires autocleavage within its function-to-find domain (FIIND)<sup>1-7</sup>. In resting cells, the dipeptidyl peptidases DPP8 and DPP9 interact with the FIIND of NLRP1 and suppress spontaneous NLRP1 activation<sup>8,9</sup>; however, the mechanisms through which this occurs remain unknown. Here we present structural and biochemical evidence that ...[more]