Ontology highlight
ABSTRACT:
SUBMITTER: Shrestha MM
PROVIDER: S-EPMC8095187 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Shrestha Man Mohan MM Lim Chun-Yan CY Bi Xuezhi X Robinson Robert C RC Han Weiping W
Frontiers in endocrinology 20210420
Insulin and muscle contractions mediate glucose transporter 4 (GLUT4) translocation and insertion into the plasma membrane (PM) for glucose uptake in skeletal muscles. Muscle contraction results in AMPK activation, which promotes GLUT4 translocation and PM insertion. However, little is known regarding AMPK effectors that directly regulate GLUT4 translocation. We aim to identify novel AMPK effectors in the regulation of GLUT4 translocation. We performed biochemical, molecular biology and fluoresc ...[more]